Download Brain Metastasis by Jerome B. Posner (auth.), Leonard Weiss Sc.D., M.D., Ph.D., PDF

By Jerome B. Posner (auth.), Leonard Weiss Sc.D., M.D., Ph.D., Harvey A. Gilbert M.D., Jerome B. Posner M.D. (eds.)

Of these humans death with melanoma, many die because of metastases. then again, a shockingly small variety of texts were dedicated to this clinically very important subject. the current sequence of monographs originated in discussions, which confident us of the necessity for texts on metasasis which might comprise not just simple and medical observations on people and the place neces­ sary, on experimental animals but in addition discussions of the state-of-the-art in prognosis and remedy. so one can do so in-depth method, for which booklet used to be preceded through small workshops, it was once essential to impose boundaries at the scope of the subject. Metastasis is consequently dis­ stubborn via web site, and the sequence is geared up for this reason. the 1st quantity within the sequence, Pulmonary Metastasis, used to be an elevated model of a Workshop held at Roswell Park Memorial Institute in 1977. This, the second one quantity, relies on the same workshop on metastasis to the mind, held on the Memorial Sloan-Kettering melanoma middle in September, 1978. In organiz­ ing either the workshop and in enhancing this quantity, we have now been excep­ tionally lucky to obtain the beneficiant cooperation of Dr. Jerome B. Posner, a training neurologic oncologist who has given freely of his ex­ pertise during this really good field.

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Neurol. Sci. 17:29-39, 1972. ; and Narvaez, R Significance of the vertebral venous (Batson's) plexus in metastatic spread in colorectal carcinoma. Cancer 40:67-71, 1977. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ A CLINICIAN'S VIEW 29 Willis, R. A. The spread of tumours in the human body. 3d ed. , 1973. Wolk, R. W. et al. and Co. The incidence of central nervous system leukemia in adults with acute leukemia. Cancer 33:863-869, 1974. Zulch, K. J. Brain tumors; their biology and pathology. 2d ed. , 1949. 2 The Cell Periphery and Metastasis Leonard Weiss The phenomenon of cancer involves the internal contents of malignant cells and their environment as well as interactions between the two.

Adv. Neurol. 19:575-587, 1978. , and Stratford, J. Carcinoma metastasis to malignant glioma. Arch. Neurol. 3:559-563, 1960. , and McKissock, W. Intracranial metastases. Br. Med. J. 1:1518, 1963. ; and Paillas, J. Etude anatomique et pathogenique des tumeurs cerebrales metastatiques. Rev. Neurol. (Paris) 72:137148, 1939. Rosenblatt, M. B. et al. Causes of death in 1,000 consecutive autopsies. N. Y. State J. Med. 71:2189-2193, 1971. , and Green, J. Solitary metastases. Springfield: Charles C Thomas, 1968.

A typical cerebral metastasis is surrounded by edema (fig. 1). At times, the edematous fluid surrounding even a small metastasis is so massive that lethal complications result from the edema itself. Less common than brain metastases are metastases to the pineal body (fig. 8) (Ortega et al. 1951), to the choroid plexus of the lateral and fourth ventricle, and to other tumors within the central nervous system. Metastases from systemic primary cancers have been reported to intracranial meningiomas (Doring 1975), to acoustic neuromas (Le Blanc 1974), and to malignant astrocytomas and ependymomas (Long 1970).

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