By Karl-Heinz Bellgardt (auth.), Prof.em.Dr.Dr.h.c Karl Schügerl, Prof. Dr. -Ing. Karl-Heinz Bellgardt (eds.)
The publication is meant to offer a variety of examples for reactor and strategy modeling and keep an eye on in addition to for metabolic flux research and metabolic layout at an advert vanced point. partly A, common rules and methods in regards to reactor and strategy versions, technique keep watch over, and metabolic flux research are awarded. additionally the accuracy, precision, and reliability of the measured info are mentioned that are ex tremely vital for technique modeling and keep an eye on. A digital bioreactor procedure is gifted to boot, which are used for the learning of scholars and operators of commercial vegetation and for the improvement of complex automation instruments. partly B, the overall rules are utilized for specific bioreactor types. It covers the appliance of the computational fluiddynamic (CFD) strategy to stirred tank and bubble column bioreactors. varied resolution tools are awarded: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with a suitable turbulence (k-ee) version, and the Euler (two fluid model), in addition to the Euler-Langrange approaches.
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Extra info for Bioreaction Engineering: Modeling and Control
Cultivation. And mostly not all interdependencies between the elementary units of the process are qualitatively and quantitatively known: The cultivation is influenced in a complicated manner by medium composition, by substrate quality and preprocessing, and by the inoculum preparation. The cultivation itself may influence the downstream processing by changing rheology of the broth and varying product properties. The situation for model building is further complicated because for batch and fed-batch operation the process is never in steady state and the model must consider the process kinetics.
T. ·". ·,. t. ·. ·. ,. ·$. ". . t. . ,. . . 1. The general layout of a biotechnical production process. stage, the major amounts of cell mass and product are formed, and emphasis is put for the process control on a high product concentration, respectively productivity. During the transfer from one reactor to the next, the broth can be further treated and might be temporarily stored to meet the scheduling for the entire plant. In big production plants, several seed or production tanks are often operated in parallel, Introduction 7 but with a certain time shift.
T. ·. ·. ,. ·$. ". . t. . ,. . . 1. The general layout of a biotechnical production process. stage, the major amounts of cell mass and product are formed, and emphasis is put for the process control on a high product concentration, respectively productivity. During the transfer from one reactor to the next, the broth can be further treated and might be temporarily stored to meet the scheduling for the entire plant. In big production plants, several seed or production tanks are often operated in parallel, Introduction 7 but with a certain time shift.