By Matthew J. Schniederjan MD, Daniel J. Brat MD PhD
It is a sensible consultant and concise reference that may be a spouse textual content for the final surgical pathologist, trainees in pathology and neuropathology, and clinicians who deal with sufferers with neurological illnesses that require surgical sampling.
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Additional info for Biopsy Interpretation of the Central Nervous System
Perinuclear clearing, or “haloes,” is a typical feature of oligodendrogliomas, but it can also decorate the cells of astrocytomas. In such cases, nuclear pleomorphism and irregularity favor astrocytic differentiation. By definition, necrosis and endothelial proliferation are absent. According to WHO grading, a single mitotic figure is not sufficient to raise the grade of an infiltrating astrocytoma to grade III. This practice is based on a large series by Giannini et al. who found no significant difference in survival between ordinary grade II lesions and those that showed a single mitotic figure .
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