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By Matthew J. Schniederjan MD, Daniel J. Brat MD PhD

It is a sensible consultant and concise reference that may be a spouse textual content for the final surgical pathologist, trainees in pathology and neuropathology, and clinicians who deal with sufferers with neurological illnesses that require surgical sampling.

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Perinuclear clearing, or “haloes,” is a typical feature of oligodendrogliomas, but it can also decorate the cells of astrocytomas. In such cases, nuclear pleomorphism and irregularity favor astrocytic differentiation. By definition, necrosis and endothelial proliferation are absent. According to WHO grading, a single mitotic figure is not sufficient to raise the grade of an infiltrating astrocytoma to grade III. This practice is based on a large series by Giannini et al. who found no significant difference in survival between ordinary grade II lesions and those that showed a single mitotic figure [14].

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Eur J Clin Microbiol Infect Dis. 2007;26(1):1–11. 35. , Brain abscess: clinical analysis of 53 cases. J Microbiol Immunol Infect. 2003;36(2):129–36. 36. Nielsen, H, C Gyldensted, and A Harmsen, Cerebral abscess. Aetiology and pathogenesis, symptoms, diagnosis and treatment. A review of 200 cases from 1935–1976. Acta Neurol Scand. 1982;65(6):609–22. 37. , Bacterial brain abscess: microbiological features, epidemiological trends and therapeutic outcomes. QJM. 2002;95(8):501–9. 38. , A twelve-year review of central nervous system bacterial abscesses: presentation and aetiology.

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