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PCR2 and PCR1 are considered to be involved in the initialization and maintenance of the repression of the gene transcription, respectively. PCR2 comprises the core components enhancer of zeste-2 (EZH2), embryonic ectoderm development (EED), and suppressor of zeste 12 (SUZ12), while PCR1 consists in a ring finger protein 1 (RING1), B lymphoma Mo-MLV insertion region 1 (BMI1) and chromobox homologue 2/4/8 (CBX2/4/8). EZH2 is the catalytic subunit of PRC2. It is a highly conserved histone methyltransferase that targets lysine 27 of histone H3.

Fig. 5. Gaussian distribution. k 1 2 3 4 Any distribution no information ≥ 75% ≥ 88% ≥ 93,75 % Normal distribution 68% 95% 99,7% 99,9% Table 4. Chebyshev’proportions compared with proportions of a normal distribution. If we decide to approximate clinical measurements by a normal curve, we are deciding to use a parametric hyphotesis test. A hypothesis test asks if an effect (difference) exists or not using statistics tests to verify the hypothesis that there is no difference. This is the null hypothesis and designated H0.

In more advanced MDS subtypes (RAEB, RAEB-t), in some cases, it has been used the chemotherapy. , 2005; Kindwall-Keller & Isola, 2009). For children with MDS, allogeneic HSCT is considered as the best treatment option (Niemeyer & Kratz, 2008). With the delineation of the characteristics that drive the biological phenotype of MDS, new drugs introduced in the treatment of this disease have shown a great therapeutic potential, such as the hypomethylant agents, called methyltransferase inhibitors (IMT).

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