Download Arachidonic Acid in Cell Signaling by Daniele Piomelli PDF

By Daniele Piomelli

This e-book is ready the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in sign transduction. Arachidonic acid may possibly function an intracellular moment messenger in lots of cellphone forms, in addition to precursor for biologically lively molecules reminiscent of the eicosanoids (a kin of oxygenated metabolites that could act as moment messengers or as neighborhood mediators), and anandamide (an endogenous cannabinoid substance). Dysfunctions within the arachidonic acid cascade underlie a couple of critical pathological stipulations, making those biochemical pathways the objective for medications of scientific value.

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6. Spector AA, Hoak ]C, Warner ED, Fry GL. Utilization of long chain fatry acids by human platelets. J Clin Invest 1970; 49: 1489-1496. 7. Wilson DB, Prescott SM, Majerus PW. Discovery of an arachidonoyl coenzyme A synthetase in human platelets. ] BioI Chern 1982; 257:3510-3515. 8. Laposata M, Reich EL, Majerus PW. Arachidonoyl-coA synthetase. Separation from nonspecific acyl-coA synthetase and distribution in various cells and tissues. J BioI Chern 1985; 260: 11 0 16-11 020. 9. Irvine R. How is the level of free arachidonate regulated?

Bennet CF, Chiang MY, Wilson-Lingardo L, Wyatt JR. Sequence specific inhibition of human type II phospholipase A2 enzyme activity by phosphorothioate oligonucleotides. Nucleic Acid Research 1994; 22:3202-3209. 68. Elmore MA, Carrier MJ, Daniels RH, Hill ME, Finnen MJ. Antisense to secretory type II phospholipase A2 inhibits fMLP-induced arachidonic acid release in differentiated HL60's. Biochemical Society Transactions 1994; 22:S 136. 69. Vial D, Piomelli D. Dopamine D2 receptors potentiate arachidonate release via activation of cytosolic, arachidonate specific phospholipase A2.

In some cases, association of group II PLA2 with cells appears to be unrelated to their non-covalent binding with membrane proteins or polysaccharides. This cell-associated form of group II PLA2 may also contribute to receptor-stimulated arachidonate mobilization • PLA2 Receplo PLA2 1P,=>cal ~ PL AA 1,2DAG~ PKC Fig. 6. Possible mechanisms for the receptor-dependent activation of type /I PLA 2 in mammalian cel/s. Shortterm mechanisms include the stimulation ofintracellularcalctum rises (shown on the right) and the stimuiatlOn of type II PLA 2 secretion {shown on the left}.

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