By Seymour Kaufman (auth.), B. W. Agranoff, M. H. Aprison (eds.)
In the Preface to quantity 1, we acknowledged: This sequence acknowledges that investigators who've entered neurochemistry from the biochemical culture have a slightly really expert view of the mind. Too frequently, interdisci plinary choices are before everything appealing yet prove to recite uncomplicated biochemical considera tions. we now have come to think that there are actually sufficiently huge numbers of neurochemists to aid a really good enterprise similar to the current one. we've got began with attention of conventional components of neurochemistry which convey huge medical task. we are hoping they'll serve the neurochemist either for basic interpreting and for specialised info. The reader also will give you the chance to mirror at the unbridled hypothesis that effects from the disinhibiting results at the writer who has been invited to write down a bankruptcy. We plan sometimes additionally to provide studies of parts now not thoroughly within the area of neurochemistry which we however consider to be sufficiently well timed to be referred to as to the eye of all who use chemical rules and instruments as a way to higher comprehend the mind. The contributions to the current quantity pursue those objectives. We think the sequence has set excessive criteria and has persevered to uphold them. in keeping with the main said within the final paragraph of the Preface quantity 1, we comprise during this quantity Koshland's "Sensory reaction in micro organism" (Chapter 5).
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It has long been recognized that the acute tolerance test, where kinetics of the change in phenylalanine levels can be measured, has great potential for differential diagnosis. , 1968). As we will see, these attempts to detect altered properties in the absence of an analysis of the factors that can influence phenylalanine tolerance results were probably premature. In order to more fully exploit the data that can be readily obtained from any patient, such as results from acute tolerance tests, it is necessary to examine normal phenylalanine metabolism in greater detail than has been done up to this point.
Thus, under the assay conditions used by McLean and co-workers, the hydroxylase activity was only about one-sixth of what it might have been if all the required components had been added. Although the detection of only a fraction of the hydroxylase activity may be a trivial. consequence of the use of this type of ill-defined assay, the uncertainty about what was actually being measured in each sample limits the value of what was potentially an extremely useful study: the determination of phenylalanine hydroxylase levels in male and female fetuses of various ages.
The results were compatible with the idea that the hydroxylase activity in classical PKU is due to the presence of either low amounts of normal hydroxylase, or a structurally altered hydroxylase with low catalytic activity. In an attempt to distinguish between these two alternatives, the kinetic properties of the hydroxylase in normal and in PKU liver were compared. The first difference is in the degree of stimulation by lysolecithin. As already mentioned (Experiment A, Table 1), the enzyme in PKU liver was -stimulated about twofold by lysolecithin.